Cord Blood transplants data | Bedomaich Chayi

Blood (hematopoietic) stem cells transplantations using cord blood units are being used at present in increasing numbers and this stem cells source is implemnted routinely in all transplant centers in Israel and abroad. Indeed, over the years, there have been a growing number of transplants that used stem cells taken from cord blood. In parallel, there has been a signicant increase in the number of cord blood units stored in public cord blood banks in order to hopefully provide good matches for more and more patients.

Although most cord blood transplants originate from donors who are unrelated to the transplanted patient, the best chances to achieve maximal match between the cord blood or bone marrow donors and the recipient patients is when donor and recipient share similar etnic or even family background.

Indeed, some cord blood transplants use cells from cord blood obtained from a sibling of the patient that is collected at the birth of the sibling in cases where the patient is already known to need stem cells/bone marrow for a transplant. Today we can even plan the genetic charctersitics of the baby in advance using pre-implantation genetic diagnosis - PGD - to ensure that the baby will be born free of the known genetic disease of the family, and at the same time ensuring that the baby contains identical tissue typing characteristics (fully matched) as the affected (patient) sibling. In such cases, cord blood is stored separately as a "designated donation" for the sick sibling. A public cord blood bank provides this service at no cost to the mother.

Following, is key data of cord blood transplants that used cord blood from the public cord blood registry of Bedomaich Chayi (updated for february 2012):

Cord blood transplants by patients' age:

Infants (up to one year)	1
Children* (2-18)	5
Adults*	7
Total	13

 

 

 

 
 

* The oldest patient to have a successful transplant with cord blood from Bedomaich Chayi was 76 years old! The youngest was two-and-a-half ! 

Cord blood units used for transplants in the following countries:

Israel	8
U.S.A.	2
France	1
Germany	1
Hungary	1

 

 

 

 

 

 

Cord blood transplants in Israel:

Hadassah Ein Kerem	3
Sheba - Tel Hashomer	2
Schneider	2
Rabin - Beilinson	1

 

 

 

 

 

Cord blood transplants by degree of matching between the patient and the stem cells:
 

6/6  (fully matched)	4
5/6  (5/6 matched)	5
4/6  (2/3 matched)	4

 

 

 

Cord blood transplants by disease:

Fanconi Anemia	1
Acute Lymphoblastic Leukemia	3
SCID – Severe Combined Immune Deficiency ("bubble children")	2
AML - Acute Myeloid Leukemia	3
MDS - Myelodysplastic Syndrome (Bone marrow disease that often leads to leukemia)	2
SDS - Diamond and Shwachman Syndrome	1
JCML - Juvenile Chronic Myelogenous Leukemia	1

 

 

 

 

 

 

 

 

 

Cord blood transplants by transplant procedure:

Single dose	5
Double transplant  (2 separate CB units)	7
Other*	1

 

 

 

 

* Combined transplantation using designated cord blood collected from a sibling at birth, in combination with stem cells collected from bone marrow of that same sibling.

 

  

Cord blood transplants by number of stem cells nucleated cells infused per dose:

0.6 to 1.0 billion	3*
1 to 1.5 billion	5
1.5 to 2.0 billion	3
Over 2 billion	2**

 

 

 

 

 

* All cord blood units containing less than 900 million cells were collected as designated donations for a sibling patient in the family. The minimum ceiling of public bank for freezing cord blood is 900 million cells, the same as other public cord blood banks worldwide.
** The largest cord blood unit ever transplanted contained over 3.4 billion stem cells nucleated cells (equivalent to almost 4 standard cord blood units). The unit was transplanted together with an additional unit for a patient who weighed 135 kg.

 

Hospitals where "designated" cord blood units were collected:

Shaare Zedek	6
Bikur Cholim	3
Maayanei Hayeshuah	3
Soroka	1

 

 

 

 

 

Cord blood transplants by years:

2009	2
2010	3
2011	6
2012	2

 

 

 

 

  

Cord blood transplants outcome:

Accepted	10
Rejected	0
No data available yet*	3

 

 

 

* Data of acceptance of cord blood transplants are usually provided to the cord blood bank within 3 months after transplantation, but this can sometimes last up to one year from the date of transplantation.